Website Description & User Guide

1. Overview

Brain Metastasis Cell Atlas (BMCA) is the public-facing atlas and data resource generated by BRIDGE Consortium, providing a publicly accessible, interactive visualization platform for cancer brain metastasis research and integrating multi-center single-cell RNA-sequencing data from multiple cancer types.

2. Data Content

The current release includes:

Data covering more than 10 types of solid tumors

Over 530 patient samples

More than 550 sequencing libraries

Over 2.5 million single-cell profiles

Major cancer types included:

Breast cancer (BRCA), colorectal cancer (CRC), lung cancer (NSCLC/SCLC), melanoma (SKCM), esophageal cancer (ESCA), gastric cancer (GC), ovarian cancer (OV), clear cell renal cell carcinoma (RCC), lymphoma (DLBCL), liver cancer (LIHC), sarcoma (SARC), etc.

For each cancer type, the platform displays:

Number of samples and cells from brain metastases (BrM)

Number of samples and cells from primary tumors

3. Application Purpose

This platform can be used to:

Quickly overview sample and cell counts across different cancer types

Compare data resources between primary tumors and brain metastases

Support study design, hypothesis generation, and data mining in metastasis research

Facilitate mechanistic, immunological, and translational studies of brain metastasis

4. Usage Instructions

An overview of all cancer types is available directly on the homepage

Displayed information includes cancer type, sample count, cell count, and origin (primary vs. metastatic)

The platform is under continuous update; advanced modules including cell annotation, subtype analysis, differential expression, and interactive visualization will be gradually launched

5. Contact & Feedback

For questions, suggestions, or collaboration inquiries, please contact us via email or the website feedback system.

All data and resources on this platform are for academic research purposes only and shall not be used for commercial applications.